Cytomegalovirus colitis unmasking human immunodeficiency virus infection as a cause of IgA vasculitis

Cytomegalovirus colitis unmasking human immunodeficiency virus infection as a cause of IgA vasculitis

Blog Article

Abstract Background Human immunodeficiency read more virus (HIV) has a protean clinical picture, in rare instances manifesting as systemic autoimmune disorders such as vasculitides.HIV-induced autoimmune diseases often do not respond well to systemic immunosuppressive therapy.Opportunistic infections may occur in patients with either acquired immunodeficiency syndrome (AIDS) or heavy immunosuppressive treatment, and can further complicate the clinical presentation.Case presentation A patient presenting with immunoglobulin A (IgA) vasculitis (IgAV) with treatment-refractory purpuric skin tennessee titans dog bandana rash and suspect intestinal vasculitis was discovered to have AIDS.HIV was the trigger of IgAV, and cytomegalovirus (CMV) colitis mimicked intestinal vasculitis.

Antiretroviral treatment improved both CMV colitis and the control of the autoimmune disease.Conclusions An autoimmune disease relapsing despite adequate immunosuppressive treatment and/or the presence of recurrent severe opportunistic infections may be clues to an underlying HIV infection.